Qihui Zhou
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Wrinkle Gradient
We developed a novel approach where well-defined surface topography gradients allowed us to determine relative feature contribution towards cell adhesion and alignment more efficiently and accurately as shown with osteoblasts as an initial test case. the number of cell culture experiments for the gradients (4) was less than for the uniform wrinkles (6) and provided more data which gave rise to better assessment of cell behavior at nanostructured interfaces. The osteoblast culture experiments show that the osteoblast behavior is influenced by small changes in surface topography. Using the model system as developed here, prospective application of this idea will
enable rapid acquisition of data for cell-biointerface interactions in order to understand the relationship between cell behavior and surface properties, required for the development of more effective biomaterials and applications in tissue engineering.
Qihui Zhou et al., Scientific Reports,2015.
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